Prof. Smita Saxena

Identification and functional analysis of disease-related mechanisms involved in spinocerebellar ataxia1 and motoneuron disease

The main focus of our research is to identify cellular mechanisms causally involved with onset and spreading of neurodegenerative diseases (ND). We use imaging and biochemical techniques combined with systems biology to identify and investigate disease-related aberrant cellular mechanisms.

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Stucki, David; Ruegsegger, Céline; Steiner, Silvio; Radecke, Julika; Murphy, MP; Zuber, Benoît; Saxena, Smita (2016). Mitochondrial impairments contribute to Spinocerebellar ataxia type 1 progression and can be ameliorated by the mitochondria-targeted antioxidant MitoQ. Free radical biology & medicine, 97, pp. 427-440. Elsevier 0.1016/j.freeradbiomed.2016.07.005

Maharjan, Niran; Künzli, Christina; Buthey, Kilian; Saxena, Smita (2016). C9ORF72 Regulates Stress Granule Formation and Its Deficiency Impairs Stress Granule Assembly, Hypersensitizing Cells to Stress (In Press). Molecular neurobiology, pp. 1-16. Springer 10.1007/s12035-016-9850-1

Ruegsegger, Céline; Saxena, Smita (2016). Proteostasis impairment in ALS. Brain research, 1648(Pt B), pp. 571-579. Elsevier 10.1016/j.brainres.2016.03.032

Maharjan, Niran; Saxena, Smita (2016). ER strikes again: Proteostasis Dysfunction In ALS. EMBO journal, 35(8), pp. 798-800. Nature Publishing Group 10.15252/embj.201694117

Ruegsegger, Céline; Maharjan, Niran; Goswami, Anand; Filézac de l’Etang, Audrey; Weis, Joachim; Troost, Dirk; Heller, Manfred; Gut, Heinz; Saxena, Smita (2016). Aberrant association of misfolded SOD1 with Na+/K+ATPase-α3 impairs its activity and contributes to motor neuron vulnerability in ALS. Acta neuropathologica, 131(3), pp. 427-451. Springer 10.1007/s00401-015-1510-4

Kudira, Ramesh; Malinka, Thomas; Kohler, Andreas; Dosch, Michel; Gomez de Agüero Tamargo, Maria de la Mercedes; Melin, Nicolas; Haegele, S; Starlinger, P; Maharjan, Niran; Saxena, Smita; Keogh, Adrian; Keogh-Stroka, Deborah M.; Candinas, Daniel; Beldi, Guido (2016). P2X1 regulated IL-22 secretion by innate lymphoid cells is required for efficient liver regeneration. Hepatology, 63(6), pp. 2004-2017. Wiley Interscience 10.1002/hep.28492

Ruegsegger, Céline; Stucki, David; Steiner, Silvio; Angliker, Nico; Radecke, Julika; Keller, Eva; Zuber, Benoît; Rüegg, Markus A; Saxena, Smita (2016). Impaired mTORC1-Dependent Expression of Homer-3 Influences SCA1 Pathophysiology. Neuron, 89(1), pp. 129-146. Cell Press 10.1016/j.neuron.2015.11.033

Neve, Anuja Vilas; Trüb, Judith; Saxena, Smita; Schümperli, Daniel (2016). Central and peripheral defects in motor units of the diaphragm of spinal muscular atrophy mice. Molecular and cellular neuroscience, 70, pp. 30-41. Elsevier 10.1016/j.mcn.2015.11.007


Filézac de L'Etang, Audrey; Maharjan, Niran; Cordeiro Braña, Marisa; Ruegsegger, Céline; Rehmann, Ruth; Goswami, Anand; Roos, Andreas; Troost, Dirk; Schneider, Bernard L; Weis, Joachim; Saxena, Smita (2015). Marinesco-Sjögren syndrome protein SIL1 regulates motor neuron subtype-selective ER stress in ALS. Nature neuroscience, 18(2), pp. 227-238. Nature America 10.1038/nn.3903


Huo, Qing; Kayikci, Melis; Odermatt, Philipp; Meyer, Kathrin; Michels, Olivia; Saxena, Smita; Ule, Jernej; Schümperli, Daniel (2014). Splicing changes in SMA mouse motoneurons and SMN-depleted neuroblastoma cells: evidence for involvement of splicing regulatory proteins. RNA biology, 11(11), pp. 1430-1446. Landes Bioscience 10.1080/15476286.2014.996494


Saxena, Smita; Roselli, Francesco; Singh, Katyayani; Leptien, Kerstin; Julien, Jean-Pierre; Gros-Louis, Francois; Caroni, Pico (2013). Neuroprotection through excitability and mTOR required in ALS motoneurons to delay disease and extend survival. Neuron, 80(1), pp. 80-96. Cell Press 10.1016/j.neuron.2013.07.027


Saxena, Smita; Caroni, Pico (2011). Selective neuronal vulnerability in neurodegenerative diseases: from stressor thresholds to degeneration. Neuron, 71(1), pp. 35-48. Cambridge, Mass.: Cell Press 10.1016/j.neuron.2011.06.031