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Research group Nowacki
Epigenetic mechanisms of complex genome editing in eukaryotes
My lab focuses on the mechanisms of RNA-mediated epigenetic inheritance in eukaryotic cells. Using ciliated protozoa as model organisms gives us the opportunity to study the very complex epigenetic phenomena accompanying the whole-genome scale developmental DNA rearrangements, where the parental cell must provide sufficient amount of information in order to produce a fully functional progeny. This involves a RNA-mediated comparison of the developing zygotic genome with the maternal somatic genome in an extraordinarily massive and precise manner.
Key words:
Epigenetics, RNA, genome rearrangement, non-Mendelian inheritance, ciliates
University of Bern
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Institute of Cell Biology |
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2011/07/27
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