Our current research areas are:
The structure and function of the parasite flagellum
We study the function of the parasite flagellum in different life cycle stages and use the Leishmania flagellum as a tractable model to study the mechanisms of movement and movement control in a eukaryotic motile cilium.
The role of parasite proton pumps in adaptation to changing environments.
We investigate how the Leishmania vacuolar H+ ATPase contributes to parasite fitness in different life cycle stages, and dissect the mechanisms by which this protein complex regulates important cellular processes.
Generation and integrative analysis of genome-wide gene deletion and protein localisation datasets to study virulence factors and organelle adaptation in Leishmania mexicana, in the collaborative LeishGEM project (www.LeishGEM.org)
