The Institute of Cell Biology performs cutting-edge research in molecular and cell biology to study a wide variety of topics that include Host Pathogen Interactions, Systems Biology, Epigenetics, Organelle Biogenesis and Developmental processes.
uniAKTUELL
Jury’s commentary │ The harmonious collective motion – reminiscent of natural phenomena at widely different scales, such as schools of fish or flocks of birds – contrast with the chaotic and destructive nature of cancer, lending a somewhat eerie beauty to an often deadly disease.
May 5, 2025
11:15 − 12:15
ICB Room C161, Baltzerstrasse 4, 3012 Bern
Special Seminar: Dr. Girish Mali | Sir William Dunn School of Pathology, University of Oxford
Invited by Prof. Dr. Eva Gluenz
PLOS ONE
The latest study from the Malaria Lab focuses on developing the next generation of malaria vaccines using genetically attenuated parasites (GAPs). By deleting two crucial genes for Plasmodium liver stage development, we demonstrate that our PbHscB-PbMei2 double-knockout (2-KO) parasite line results in a complete developmental arrest at this critical stage. This groudbreaking discovery paves the way for future vaccine designs targeting the Plasmodium liver stage, thereby preventing the symptomatic blood phase of malaria.
Melanie Schmid*, Raphael Beyeler*, Reto Caldelari, Ruth Rehmann, Volker Heussler and Magali Roques
Gluenz Lab
In a new study published in Science, the Gluenz lab investigated motility mechanisms of Leishmania parasites. The Brown lab at Harvard mapped the structure of the Leishmania axonemal microtubule doublets by cryo-EM and Sophia Fochler and former Gluenz lab members Tom Beneke and James Smith used CRISPR gene editing to manipulate individual building blocks from this structure to identify proteins that are crucial for movement.
Matthew H. Doran et al. Science 387, eadr5507(2025). DOI:10.1126/science.adr5507
Baltzerstrasse 4 3012 Bern
