Institute of Cell Biology


Prof. Dr. Eduardo Moreno

Cell Fitness: Genetic and Molecular studies

Humans are able to detect fitness decay in colleagues by looking at the graying of the hair or the wrinkles in their faces. Work from my laboratory in the last few years has shown that cells can also detect fitness levels of neighboring cells using a molecular code. Those "fitness fingerprints" (Rhiner et al., Dev.Cell, 2010; Merino et al., Curr. Biol., 2013) can be used to mediate cell selection by recognizing and eliminating less fit cells during ageing (Merino et al., Cell, 2015), regeneration (Moreno et al., Curr. Biol., 2015) and cancer (Levayer et al., Nature 2015).

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Moreno, Eduardo; Levayer, Romain (2016). How to be in a good shape? The influence of clone morphology on cell competition. Communicative & integrative biology, 9(1), e1102806. Landes Bioscience 10.1080/19420889.2015.1102806

Moreno, Eduardo; Levayer, Romain; Dupont, Carole (2016). Tissue Crowding Induces Caspase-Dependent Competition for Space. Current Biology, 26(5), pp. 670-677. Cell Press 10.1016/j.cub.2015.12.072


Moreno, Eduardo; Gogna, Rajan; Shee, Kevin (2015). Cell Competition During Growth and Regeneration. Annual Review of Genetics, 49, pp. 697-718. Annual Reviews 10.1146/annurev-genet-112414-055214

Moreno, Eduardo; Casas-Tintó, S; Lolo, FN (2015). Active JNK-dependent secretion of Drosophila Tyrosyl-tRNA synthetase by loser cells recruits haemocytes during cell competition. Nature communications, 6(10022), pp. 1-12. Nature Publishing Group 10.1038/ncomms10022

Moreno, Eduardo; Hauert, Barbara; Levayer, Romain (2015). Cell mixing induced by myc is required for competitive tissue invasion and destruction. Nature, 524(7566), pp. 476-480. Macmillan Journals Ltd. 10.1038/nature14684

Moreno, Eduardo; Zhang, C; Casas-Tintó, S; Li, G; Lin, N; Chung, M; Moberg, K H; Zhou, L (2015). An Intergenic Regulatory Region Mediates Drosophila Myc -Induced Apoptosis and Blocks Tissue Hyperplasia. Oncogene, 34(18), pp. 2385-2397. Nature Publishing Group 10.1038/onc.2014.160


Moreno, Eduardo; Rhiner, Christa (2014). Darwin's multicellularity: from neurotrophic theories and cell competition to fitness fingerprints. Current opinion in cell biology, 31, pp. 16-22. Elsevier 10.1016/

Gupta, Kartik; Madan, Esha; Sayyid, Muzzammil; Arias-Pulido, Hugo; Moreno, Eduardo; Kuppusamy, Periannan; Gogna, Rajan (2014). Oxygen regulates molecular mechanisms of cancer progression and metastasis. Cancer and Metastasis Reviews, 33(1), pp. 183-215. Springer 10.1007/s10555-013-9464-2

Moreno, Eduardo (2014). Cancer: Darwinian tumour suppression. Nature, 509(7501), pp. 435-436. Macmillan Journals Ltd. 10.1038/nature13337


Merino, Marisa M.; Rhiner, Christa; Portela, Marta; Moreno, Eduardo (2013). “Fitness Fingerprints” Mediate Physiological Culling of Unwanted Neurons in Drosophila. Current Biology, 23(14), pp. 1300-1309. Cell Press 10.1016/j.cub.2013.05.053

Fernández Hernández, Ismael; Rhiner, Christa; Moreno, Eduardo (2013). Adult Neurogenesis in Drosophila. Cell reports, 3(6), pp. 1857-1865. Cell Press 10.1016/j.celrep.2013.05.034

Moreno, Eduardo (2013). The “Out of Africa Tribe” (II): Paleolithic warriors with big canoes and protective weapons. Communicative & integrative biology, 6(3), e24145. Landes Bioscience 10.4161/cib.24145

Lolo, Fidel-Nicolás; Tintó, Sergio Casas; Moreno, Eduardo (2013). How winner cells cause the demise of loser cells. BioEssays, 35(4), pp. 348-353. Wiley 10.1002/bies.201200156

Levayer, Romain; Moreno, Eduardo (2013). Mechanisms of cell competition: Themes and variations. Journal of cell biology, 200(6), pp. 689-698. Rockefeller Institute Press 10.1083/jcb.201301051


Petrova, E.; López-Gay, J.M.; Rhiner, C.; Moreno, E. (2012). Flower-deficient mice have reduced susceptibility to skin papilloma formation. Disease models & mechanisms, 5(4), pp. 553-561. Cambridge: Company of Biologists Ltd. 10.1242/dmm.008623

Moreno, E. (2012). Design and Construction of "Synthetic Species". PLoS ONE, 7(7), e39054. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0039054

Lolo, F.; Casas-Tinto, S.; Moreno, E. (2012). Cell competition time line: winners kill losers, which are extruded and engulfed by hemocytes. Cell reports, 2(3), pp. 526-539. Cambridge, Mass.: Cell Press 10.1016/j.celrep.2012.08.012


Casas-Tinto, Sergio; Torres, Miguel; Moreno, Eduardo (2011). The "Flower Code" and Cancer Development. Clinical & translational oncology, 13(1), pp. 5-9. Madrid: Feseo 10.1007/s12094-011-0610-4

Petrova, Evgeniya; Soldini, Davide; Moreno, Eduardo (2011). The expression of SPARC in human tumors is consistent with its role during cell competition. Communicative & integrative biology, 4(2), pp. 171-174. Austin, Tex.: Landes Bioscience 10.4161/cib.4.2.14232

Moreno, Eduardo (2011). The society of our "out of Africa" ancestors (I): The migrant warriors that colonized the world. Communicative & integrative biology, 2(163-170), p. 8. Austin, Tex.: Landes Bioscience 10.4161/cib.4.2.14320

Moreno, Eduardo (2011). Design and construction of a new Drosophila species, D.synthetica, by synthetic regulatory evolution. Nature precedings - pre-publication research and preliminary findings London: Nature Publishing Group

Moreno, Eduardo; y López-Gay, Jesús M. (2011). Competición celular: las guerras floridas. Investigación y ciencia - edición en español de Scientific American, 419(130-133), p. 4. Barcelona: Prensa Cientifica

  • 2014: ERC Consolidator Grant Award
  • 2012: ERC Proof of Concept Award
  • 2011: Josef Steiner Cancer Research Award
  • 2007: ERC Young Investigator Award
  • 2002: CBM-UAM PIMP prize
  • 2002: Brupbacher Foundation Young Investigator Prize, Zurich
  • 1999: Extraordinary Prize for the best thesis Universidad Autónoma Madrid
  • 1999: Innogenetics-SEBBM Young Scientists Prize