Prof. Dr. Benjamin Towbin

Our laboratory explores the fundamental design principles governing molecular circuits at the multicellular level. We employ a combination of quantitative experiments and computational approaches, using the nematode C. elegans as our model organism. Experimentally, we specialize in quantitative live imaging and computational image analysis, high-throughput screens, and in the precise spatio-temporal perturbation of molecular circuits.

Current Research Focus

Developmental Robustness: Orchestrating Cellular Growth

How do an animal's cells coordinate their growth to consistently produce an appropriate body plan?

During development, organs grow exponentially by orders of magnitude. Therefore, small fluctuations in the growth rate can, in principle, amplify to significant size discrepancies. Yet, in nature, organ proportions are remarkably consistent across individuals. We investigate the molecular mechanisms that coordinate growth across different organs and thereby ensure this robustness.

Developmental Plasticity: Thriving under Nutritional Fluctuations

How do animals optimize their fitness in response to changing nutritional conditions?

Animals must navigate environments where food availability fluctuates. This requires a delicate balance between rapid growth during abundance and survival during scarcity. We investigate the molecular mechanisms that sense nutritional cues, how they alter gene expression, and how this regulation ultimately impacts organism-scale phenotypes, such as growth, reproduction, and aging. We thereby strive to understand the molecular underpinnings of tradeoffs between these fundamental life history traits and how animals navigate these tradeoffs to make the best out of their environment.

Together, we aim to learn how organisms maintain robustness within an environment yet remain plastic across different environments.

 

Group Towbin

Post Docs

Technicians

PhD students

Publication Year Type

Live microscopy

AI-driven image analysis

Genetic screens

Mathematical modelling

We are always interested in motivated talent and can explore possible projects and funding opportunities, including  postdoctoral fellowships from EMBO, MSCA,  HFSP, or FEBS. Please get in touch by email providing your CV, a motivation letter, and a statement of research interests.

Undergraduates looking for training opportunities: Please get in touch by email!